PNPLA3

Entrez Summary: The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008].
UniProt Summary: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. {ECO:0000269|PubMed:15364929}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

diolein transacylation activity
mono-olein transacylation activity
triglyceride acyl-chain remodeling
lysophosphatidic acid acyltransferase activity
lysophosphatidic acid binding
long-chain fatty acyl-CoA binding
acylglycerol acyl-chain remodeling
1-acylglycerol-3-phosphate O-acyltransferase activity
triglyceride biosynthetic process
lipid droplet organization
triglyceride lipase activity
neutral lipid biosynthetic process
acylglycerol biosynthetic process
triglyceride catabolic process
phospholipase A2 activity
acylglycerol catabolic process
neutral lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
glycerolipid catabolic process
triglyceride metabolic process
lipid droplet
acylglycerol metabolic process
neutral lipid metabolic process
long-chain fatty acid metabolic process
lipid homeostasis
cellular lipid catabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
lipid catabolic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
monocarboxylic acid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process