POFUT2 [The Human Chemical-Genetic Interaction Map Project]

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======= POFUT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POFUT2
  * **<color #00a2e8>Official Name</color>**: protein O-fucosyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23275|23275]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2G5|Q9Y2G5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POFUT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POFUT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610249|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. {ECO:0000250, ECO:0000269|PubMed:11067851, ECO:0000269|PubMed:16464858, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|O-FucT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide-O-fucosyltransferase activity|
|protein O-linked fucosylation|
|fucose metabolic process|
|fucosylation|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of epithelial to mesenchymal transition|
|protein O-linked glycosylation|
|formation of primary germ layer|
|mesoderm development|
|hexose metabolic process|
|gastrulation|
|monosaccharide metabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|carbohydrate derivative biosynthetic process|
|regulation of secretion|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|embryo development|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.01|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.72|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.88|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.06|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POFUT2 Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>