POFUT2

Entrez Summary: N/A
UniProt Summary: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. {ECO:0000250, ECO:0000269|PubMed:11067851, ECO:0000269|PubMed:16464858, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptide-O-fucosyltransferase activity
protein O-linked fucosylation
fucose metabolic process
fucosylation
mesoderm formation
mesoderm morphogenesis
regulation of epithelial to mesenchymal transition
protein O-linked glycosylation
formation of primary germ layer
mesoderm development
hexose metabolic process
gastrulation
monosaccharide metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
tissue morphogenesis
embryonic morphogenesis
carbohydrate derivative biosynthetic process
regulation of secretion
anatomical structure formation involved in morphogenesis
endoplasmic reticulum membrane
embryo development
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
tissue development
macromolecule biosynthetic process
regulation of cell differentiation
regulation of transport