POLB

Entrez Summary: N/A
UniProt Summary: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9572863}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-3.55
Rucaparib 6.5μM R08 exp520	-3.21
Temozolomide 200μM R04 exp189	-2.14
D-Fructose 10000μM R06 exp279	-1.8
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.7
QNZ 0.01μM R05 exp241	1.73
ML-792 0.2μM R08 exp505	1.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

immunoglobulin heavy chain V-D-J recombination
base-excision repair, base-free sugar-phosphate removal
DNA dephosphorylation
base-excision repair, DNA ligation
immunoglobulin V(D)J recombination
base-excision repair, gap-filling
DNA ligation involved in DNA repair
pyrimidine dimer repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
DNA ligation
lyase activity
lymph node development
V(D)J recombination
somatic hypermutation of immunoglobulin genes
somatic diversification of immune receptors via somatic mutation
response to hyperoxia
somatic recombination of immunoglobulin gene segments
nucleotide-excision repair, DNA gap filling
DNA-directed DNA polymerase activity
response to increased oxygen levels
salivary gland morphogenesis
salivary gland development
spleen development
somatic diversification of immune receptors via germline recombination within a single locus
somatic cell DNA recombination
somatic diversification of immunoglobulins
spindle microtubule
base-excision repair
exocrine system development
neuron apoptotic process
somatic diversification of immune receptors
neuron death
damaged DNA binding
response to gamma radiation
double-strand break repair via nonhomologous end joining
non-recombinational repair
intrinsic apoptotic signaling pathway in response to DNA damage
gland morphogenesis
DNA biosynthetic process
nucleotide-excision repair