POLD4

Entrez Summary: N/A
UniProt Summary: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break- induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480). {ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24022480, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

delta DNA polymerase complex
nucleotide-excision repair, DNA gap filling
telomere maintenance via semi-conservative replication
DNA-directed DNA polymerase activity
mismatch repair
nucleotide-excision repair, DNA incision, 5-to lesion
DNA damage response, detection of DNA damage
nucleotide-excision repair, DNA incision
translesion synthesis
nuclear DNA replication
cell cycle DNA replication
DNA synthesis involved in DNA repair
postreplication repair
transcription-coupled nucleotide-excision repair
telomere maintenance
telomere organization
DNA biosynthetic process
nucleotide-excision repair
DNA-dependent DNA replication
DNA replication
nucleic acid phosphodiester bond hydrolysis
anatomical structure homeostasis
DNA repair
detection of stimulus
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus
cellular homeostasis
cell cycle process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
cell cycle
cellular nitrogen compound biosynthetic process
homeostatic process
cellular response to stress
cellular macromolecule biosynthetic process