POLE4

Entrez Summary: N/A
UniProt Summary: May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.64
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.42
Deferoxamine 11μM R07 exp350	-2.04
Fluvastatin 2.2μM R06 exp282	-1.88
Campthothecin 0.001μM R06 exp270	-1.86
QNZ 0.01μM R08 exp439	1.9

Global Fraction of Cell Lines Where Essential: 8/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/25
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	3/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Histone
CBFD NFYB HMF

epsilon DNA polymerase complex
Ada2/Gcn5/Ada3 transcription activator complex
telomere maintenance via semi-conservative replication
DNA-directed DNA polymerase activity
DNA replication initiation
nuclear DNA replication
cell cycle DNA replication
histone H3 acetylation
telomere maintenance
telomere organization
DNA biosynthetic process
histone acetylation
internal peptidyl-lysine acetylation
G1/S transition of mitotic cell cycle
DNA-dependent DNA replication
cell cycle G1/S phase transition
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
protein acylation
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
peptidyl-lysine modification
anatomical structure homeostasis
histone modification
covalent chromatin modification
protein heterodimerization activity
mitotic cell cycle process
mitotic cell cycle
chromatin organization
DNA metabolic process
peptidyl-amino acid modification
cellular homeostasis
cell cycle process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process