POLR1E [The Human Chemical-Genetic Interaction Map Project]

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======= POLR1E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR1E
  * **<color #00a2e8>Official Name</color>**: RNA polymerase I subunit E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64425|64425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZS1|Q9GZS1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR1E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR1E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621031|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol I A49|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I general transcription initiation factor binding|
|nucleolar large rRNA transcription by RNA polymerase I|
|RNA polymerase I preinitiation complex assembly|
|RNA polymerase I activity|
|RNA polymerase I complex|
|rRNA transcription|
|transcription elongation from RNA polymerase I promoter|
|transcription preinitiation complex assembly|
|termination of RNA polymerase I transcription|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|fibrillar center|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular protein-containing complex assembly|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.09|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.73|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.1|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 361/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|14/28|
|bone|8/26|
|breast|11/33|
|central nervous system|32/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|19/21|
|liver|8/20|
|lung|40/75|
|lymphocyte|7/16|
|ovary|12/26|
|pancreas|16/24|
|peripheral nervous system|5/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1357
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR1E Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>