POLR1E

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 361/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	13/28
blood	14/28
bone	8/26
breast	11/33
central nervous system	32/56
cervix	2/4
colorectal	8/17
esophagus	12/13
fibroblast	0/1
gastric	5/16
kidney	19/21
liver	8/20
lung	40/75
lymphocyte	7/16
ovary	12/26
pancreas	16/24
peripheral nervous system	5/16
plasma cell	1/15
prostate	0/1
skin	14/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	13/22
urinary tract	13/29
uterus	2/5

Expression Distribution

RNA polymerase I general transcription initiation factor binding
nucleolar large rRNA transcription by RNA polymerase I
RNA polymerase I preinitiation complex assembly
RNA polymerase I activity
RNA polymerase I complex
rRNA transcription
transcription elongation from RNA polymerase I promoter
transcription preinitiation complex assembly
termination of RNA polymerase I transcription
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
ncRNA transcription
fibrillar center
protein-DNA complex assembly
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleolus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
positive regulation of gene expression
gene expression