POLR3K

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 719/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	19/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

TFIIS C
RNA POL M 15KD

termination of RNA polymerase III transcription
tRNA 3-trailer cleavage
tRNA 3-end processing
RNA polymerase III activity
RNA polymerase III complex
DNA-directed 5-3 RNA polymerase activity
transcription by RNA polymerase III
ncRNA 3-end processing
DNA-templated transcription, termination
positive regulation of type I interferon production
regulation of type I interferon production
tRNA processing
RNA 3-end processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
defense response to virus
nucleic acid binding
response to virus
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
positive regulation of cytokine production
ncRNA metabolic process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of cytokine production
innate immune response
zinc ion binding
nucleolus
RNA processing
defense response to other organism
immune effector process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
response to other organism
organic cyclic compound biosynthetic process
response to external biotic stimulus
response to biotic stimulus
defense response