POMT2 [The Human Chemical-Genetic Interaction Map Project]

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======= POMT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POMT2
  * **<color #00a2e8>Official Name</color>**: protein O-mannosyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29954|29954]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKY4|Q9UKY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POMT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POMT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607439|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. {ECO:0000269|PubMed:14699049}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIR|
|PMT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein O-linked glycosylation|
|regulation of protein O-linked glycosylation|
|positive regulation of protein glycosylation|
|dolichyl-phosphate-mannose-protein mannosyltransferase activity|
|ER-associated misfolded protein catabolic process|
|regulation of protein glycosylation|
|protein O-linked mannosylation|
|positive regulation of glycoprotein biosynthetic process|
|mannosyltransferase activity|
|positive regulation of glycoprotein metabolic process|
|cellular response to misfolded protein|
|response to misfolded protein|
|protein mannosylation|
|protein quality control for misfolded or incompletely synthesized proteins|
|mannosylation|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|ERAD pathway|
|protein O-linked glycosylation|
|cellular response to topologically incorrect protein|
|response to topologically incorrect protein|
|protein glycosylation|
|macromolecule glycosylation|
|response to endoplasmic reticulum stress|
|glycosylation|
|glycoprotein biosynthetic process|
|proteasomal protein catabolic process|
|glycoprotein metabolic process|
|proteolysis involved in cellular protein catabolic process|
|carbohydrate derivative biosynthetic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|response to organonitrogen compound|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|positive regulation of protein modification process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.84|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.71|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7184
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POMT2 Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>