POMT2

Gene Information

Official Symbol: POMT2
Official Name: protein O-mannosyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 29954
UniProt: Q9UKY4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq, Oct 2008].
UniProt Summary: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. {ECO:0000269|PubMed:14699049}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7184
Expression level (log2 read counts): 4.86

Expression Distribution

Screen	Score
VER-155008 3.9μM R06 exp301	-1.84
CyclicAMP 200μM R08 exp475	1.71
Tanespimycin 14μM R08 exp527	1.78

MIR
PMT

positive regulation of protein O-linked glycosylation
regulation of protein O-linked glycosylation
positive regulation of protein glycosylation
dolichyl-phosphate-mannose-protein mannosyltransferase activity
ER-associated misfolded protein catabolic process
regulation of protein glycosylation
protein O-linked mannosylation
positive regulation of glycoprotein biosynthetic process
mannosyltransferase activity
positive regulation of glycoprotein metabolic process
cellular response to misfolded protein
response to misfolded protein
protein mannosylation
protein quality control for misfolded or incompletely synthesized proteins
mannosylation
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
ERAD pathway
protein O-linked glycosylation
cellular response to topologically incorrect protein
response to topologically incorrect protein
protein glycosylation
macromolecule glycosylation
response to endoplasmic reticulum stress
glycosylation
glycoprotein biosynthetic process
proteasomal protein catabolic process
glycoprotein metabolic process
proteolysis involved in cellular protein catabolic process
carbohydrate derivative biosynthetic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
endoplasmic reticulum membrane
response to organonitrogen compound
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
positive regulation of protein modification process