POP4 [The Human Chemical-Genetic Interaction Map Project]

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======= POP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POP4
  * **<color #00a2e8>Official Name</color>**: POP4 homolog, ribonuclease P/MRP subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10775|10775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95707|O95707]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606114|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0086|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonuclease P complex|
|ribonuclease MRP activity|
|ribonuclease MRP complex|
|multimeric ribonuclease P complex|
|ribonuclease P RNA binding|
|ribonuclease P activity|
|tRNA 5-leader removal|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|tRNA processing|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.87|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.71|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.74|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.8|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 943
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POP4 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>