POP4

Entrez Summary: N/A
UniProt Summary: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	3/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

ribonuclease P complex
ribonuclease MRP activity
ribonuclease MRP complex
multimeric ribonuclease P complex
ribonuclease P RNA binding
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA metabolic process
gene expression