POU2AF1 [The Human Chemical-Genetic Interaction Map Project]

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======= POU2AF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU2AF1
  * **<color #00a2e8>Official Name</color>**: POU class 2 homeobox associating factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5450|5450]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16633|Q16633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU2AF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU2AF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PD-C2-AF1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II core promoter sequence-specific DNA binding|
|RNA polymerase II transcription factor complex|
|transcription coregulator activity|
|transcription coactivator activity|
|humoral immune response|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.1|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.85|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.79|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.74|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.73|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.71|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.72|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.76|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.89|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.99|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.1|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.17|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.19|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.89|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bcor|BCOR]]|0.521|
|[[:human genes:u:ube2e1|UBE2E1]]|0.5|
|[[:human genes:i:ikzf2|IKZF2]]|0.49|
|[[:human genes:r:ring1|RING1]]|0.483|
|[[:human genes:p:pcgf1|PCGF1]]|0.465|
|[[:human genes:y:ypel5|YPEL5]]|0.426|
|[[:human genes:a:akirin1|AKIRIN1]]|0.411|
|[[:human genes:g:glyr1|GLYR1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16774
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU2AF1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>