POU2AF1

Entrez Summary: N/A
UniProt Summary: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 1μM R01 exp59	-2.1
HMS-I1 1μM R01 exp46	-1.85
Resveratrol 16μM R03 exp147	-1.79
Pterostilbene 16μM R02 exp78	-1.74
MK-1775 0.32μM R02 exp75	-1.73
CI-1040 9.5μM R08 exp472	-1.71
Glyphosate 1000μM R06 exp283	1.72
Thapsigargin 0.005μM R07 exp407	1.76
Tubacin 1.6μM R07 exp416	1.89
Dimethyloxaloylglycine 11μM R07 exp314	1.99
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.1
TRAIL 5ng/ml R00 exp35	2.17
Dimethyloxaloylglycine 100μM R05 exp229	2.19
TRAIL 50ng/ml R00 exp36	2.89
Bortezomib 0.005μM R00 exp6	3.14

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor complex
transcription coregulator activity
transcription coactivator activity
humoral immune response
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
immune response
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process