POU2F2 [The Human Chemical-Genetic Interaction Map Project]

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======= POU2F2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU2F2
  * **<color #00a2e8>Official Name</color>**: POU class 2 homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5452|5452]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09086|P09086]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU2F2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU2F2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164176|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pou|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immunoglobulin secretion involved in immune response|
|immunoglobulin secretion|
|mature B cell differentiation|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|B cell differentiation|
|B cell activation|
|immunoglobulin production|
|protein secretion|
|cell maturation|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|production of molecular mediator of immune response|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|lymphocyte differentiation|
|developmental maturation|
|protein domain specific binding|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte differentiation|
|humoral immune response|
|lymphocyte activation|
|sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|leukocyte mediated immunity|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|nitrogen compound transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4953
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU2F2 Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>