POU2F2

Entrez Summary: The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pou
Homeobox

immunoglobulin secretion involved in immune response
immunoglobulin secretion
mature B cell differentiation
immunoglobulin production involved in immunoglobulin mediated immune response
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
B cell differentiation
B cell activation
immunoglobulin production
protein secretion
cell maturation
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
production of molecular mediator of immune response
immunoglobulin mediated immune response
B cell mediated immunity
lymphocyte differentiation
developmental maturation
protein domain specific binding
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
leukocyte differentiation
humoral immune response
lymphocyte activation
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
hemopoiesis
hematopoietic or lymphoid organ development
adaptive immune response
transcription, DNA-templated
nucleic acid-templated transcription
immune system development
RNA biosynthetic process
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
leukocyte mediated immunity