POU3F3

Entrez Summary: N/A
UniProt Summary: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
Pou

metanephric juxtaglomerular apparatus development
macula densa development
metanephric DCT cell differentiation
DCT cell differentiation
metanephric macula densa development
juxtaglomerular apparatus development
metanephric thick ascending limb development
thick ascending limb development
metanephric ascending thin limb development
ascending thin limb development
distal convoluted tubule development
metanephric distal convoluted tubule development
metanephric loop of Henle development
forebrain ventricular zone progenitor cell division
metanephric distal tubule development
loop of Henle development
distal tubule development
metanephric nephron tubule development
HMG box domain binding
cell differentiation involved in metanephros development
metanephric nephron epithelium development
metanephric tubule development
metanephric epithelium development
cell proliferation in forebrain
cerebral cortex radially oriented cell migration
excretion
cell differentiation involved in kidney development
cerebral cortex cell migration
telencephalon cell migration
forebrain cell migration
neural precursor cell proliferation
nephron tubule development
renal tubule development
metanephros development
nephron epithelium development
cerebral cortex development
nephron development
kidney epithelium development
pallium development
telencephalon development