POU3F4

Entrez Summary: This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012].
UniProt Summary: Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Pou
Homeobox

negative regulation of mesenchymal cell apoptotic process
regulation of mesenchymal cell apoptotic process
cochlea morphogenesis
cochlea development
inner ear morphogenesis
ear morphogenesis
sensory perception of sound
sensory perception of mechanical stimulus
inner ear development
ear development
sensory organ morphogenesis
embryonic organ morphogenesis
sequence-specific DNA binding
embryonic organ development
sensory organ development
embryonic morphogenesis
DNA-binding transcription factor activity
brain development
head development
negative regulation of apoptotic process
negative regulation of programmed cell death
animal organ morphogenesis
sensory perception
embryo development
central nervous system development
negative regulation of cell death
nervous system process
regulation of apoptotic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
regulation of cell death
system process