PPA2 [The Human Chemical-Genetic Interaction Map Project]

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======= PPA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPA2
  * **<color #00a2e8>Official Name</color>**: inorganic pyrophosphatase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27068|27068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2U2|Q9H2U2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609988|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyrophosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diphosphate metabolic process|
|inorganic diphosphatase activity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|protein serine/threonine phosphatase activity|
|regulation of mitochondrial membrane potential|
|tRNA metabolic process|
|protein dephosphorylation|
|magnesium ion binding|
|dephosphorylation|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|regulation of membrane potential|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.84|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.86|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dohh|DOHH]]|0.586|
|[[:human genes:t:triap1|TRIAP1]]|0.578|
|[[:human genes:t:thg1l|THG1L]]|0.563|
|[[:human genes:s:srp14|SRP14]]|0.554|
|[[:human genes:h:hccs|HCCS]]|0.551|
|[[:human genes:d:dhrsx|DHRSX]]|0.551|
|[[:human genes:a:atp5a1|ATP5A1]]|0.55|
|[[:human genes:g:gfpt1|GFPT1]]|0.548|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.536|
|[[:human genes:a:atxn10|ATXN10]]|0.536|
|[[:human genes:c:cycs|CYCS]]|0.534|
|[[:human genes:l:lsm10|LSM10]]|0.529|
|[[:human genes:p:pmm2|PMM2]]|0.529|
|[[:human genes:u:uap1|UAP1]]|0.528|
|[[:human genes:d:dap3|DAP3]]|0.527|
|[[:human genes:d:dpagt1|DPAGT1]]|0.523|
|[[:human genes:a:atp5b|ATP5B]]|0.52|
|[[:human genes:a:alg5|ALG5]]|0.519|
|[[:human genes:g:gmppb|GMPPB]]|0.517|
|[[:human genes:m:mrps33|MRPS33]]|0.513|
|[[:human genes:o:opa1|OPA1]]|0.511|
|[[:human genes:p:pgm3|PGM3]]|0.511|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.51|
|[[:human genes:a:atp5j|ATP5J]]|0.508|
|[[:human genes:a:apaf1|APAF1]]|0.507|
|[[:human genes:c:chchd4|CHCHD4]]|0.507|
|[[:human genes:r:rnmt|RNMT]]|0.505|
|[[:human genes:k:kdsr|KDSR]]|0.505|
|[[:human genes:a:alg1|ALG1]]|0.503|
|[[:human genes:y:yars2|YARS2]]|0.503|
|[[:human genes:a:atp5d|ATP5D]]|0.501|
|[[:human genes:t:taz|TAZ]]|0.501|
|[[:human genes:c:casp9|CASP9]]|0.5|
|[[:human genes:f:fh|FH]]|0.499|
|[[:human genes:s:slc25a26|SLC25A26]]|0.497|
|[[:human genes:m:mrpl21|MRPL21]]|0.497|
|[[:human genes:a:alg13|ALG13]]|0.496|
|[[:human genes:b:bak1|BAK1]]|0.492|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.49|
|[[:human genes:c:cbfb|CBFB]]|0.489|
|[[:human genes:a:alg6|ALG6]]|0.488|
|[[:human genes:s:ssb|SSB]]|0.488|
|[[:human genes:m:mrpl23|MRPL23]]|0.485|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.484|
|[[:human genes:e:elac2|ELAC2]]|0.483|
|[[:human genes:t:tamm41|TAMM41]]|0.483|
|[[:human genes:d:dolk|DOLK]]|0.482|
|[[:human genes:r:rft1|RFT1]]|0.481|
|[[:human genes:h:hspd1|HSPD1]]|0.481|
|[[:human genes:e:exoc4|EXOC4]]|0.479|
|[[:human genes:b:bap1|BAP1]]|0.479|
|[[:human genes:z:zrsr2|ZRSR2]]|0.478|
|[[:human genes:r:rpia|RPIA]]|0.478|
|[[:human genes:r:rtcb|RTCB]]|0.478|
|[[:human genes:m:mrps5|MRPS5]]|0.477|
|[[:human genes:m:mrps14|MRPS14]]|0.475|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.475|
|[[:human genes:t:tufm|TUFM]]|0.474|
|[[:human genes:v:vezt|VEZT]]|0.473|
|[[:human genes:c:cept1|CEPT1]]|0.471|
|[[:human genes:v:vps41|VPS41]]|0.471|
|[[:human genes:p:ppcs|PPCS]]|0.471|
|[[:human genes:r:rptor|RPTOR]]|0.47|
|[[:human genes:a:atp5o|ATP5O]]|0.47|
|[[:human genes:g:gfm1|GFM1]]|0.469|
|[[:human genes:m:mrps16|MRPS16]]|0.465|
|[[:human genes:m:mrps6|MRPS6]]|0.465|
|[[:human genes:b:bcs1l|BCS1L]]|0.464|
|[[:human genes:d:dhps|DHPS]]|0.46|
|[[:human genes:r:rbfa|RBFA]]|0.459|
|[[:human genes:d:dars2|DARS2]]|0.459|
|[[:human genes:m:mrps34|MRPS34]]|0.458|
|[[:human genes:l:lsm11|LSM11]]|0.458|
|[[:human genes:u:ube2g2|UBE2G2]]|0.458|
|[[:human genes:m:mrp63|MRP63]]|0.458|
|[[:human genes:t:tars2|TARS2]]|0.458|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.456|
|[[:human genes:t:timm22|TIMM22]]|0.455|
|[[:human genes:g:gatc|GATC]]|0.454|
|[[:human genes:s:srd5a3|SRD5A3]]|0.453|
|[[:human genes:t:ten1|TEN1]]|0.45|
|[[:human genes:a:atp2a2|ATP2A2]]|0.45|
|[[:human genes:g:gemin7|GEMIN7]]|0.448|
|[[:human genes:n:nbn|NBN]]|0.448|
|[[:human genes:a:adsl|ADSL]]|0.447|
|[[:human genes:r:romo1|ROMO1]]|0.445|
|[[:human genes:a:atp5f1|ATP5F1]]|0.444|
|[[:human genes:u:uhrf1|UHRF1]]|0.441|
|[[:human genes:w:wbscr16|WBSCR16]]|0.44|
|[[:human genes:m:mrpl15|MRPL15]]|0.439|
|[[:human genes:c:crls1|CRLS1]]|0.438|
|[[:human genes:p:pggt1b|PGGT1B]]|0.437|
|[[:human genes:m:mrps18a|MRPS18A]]|0.436|
|[[:human genes:f:faf2|FAF2]]|0.435|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.435|
|[[:human genes:r:rars2|RARS2]]|0.434|
|[[:human genes:m:mrpl47|MRPL47]]|0.434|
|[[:human genes:s:sdha|SDHA]]|0.434|
|[[:human genes:m:mrps9|MRPS9]]|0.432|
|[[:human genes:d:dnlz|DNLZ]]|0.431|
|[[:human genes:m:mrps21|MRPS21]]|0.431|
|[[:human genes:p:plaa|PLAA]]|0.43|
|[[:human genes:u:ube2m|UBE2M]]|0.43|
|[[:human genes:m:mrps26|MRPS26]]|0.429|
|[[:human genes:s:sars2|SARS2]]|0.428|
|[[:human genes:e:eif3f|EIF3F]]|0.428|
|[[:human genes:p:pik3r4|PIK3R4]]|0.428|
|[[:human genes:t:tbca|TBCA]]|0.426|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.426|
|[[:human genes:m:mrpl53|MRPL53]]|0.426|
|[[:human genes:e:eny2|ENY2]]|0.425|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.424|
|[[:human genes:p:prkrir|PRKRIR]]|0.424|
|[[:human genes:p:pars2|PARS2]]|0.422|
|[[:human genes:p:ppp4c|PPP4C]]|0.422|
|[[:human genes:p:ppcdc|PPCDC]]|0.42|
|[[:human genes:n:ndufb1|NDUFB1]]|0.418|
|[[:human genes:t:trmt61a|TRMT61A]]|0.418|
|[[:human genes:t:trnt1|TRNT1]]|0.418|
|[[:human genes:m:mrpl20|MRPL20]]|0.417|
|[[:human genes:c:cox16|COX16]]|0.416|
|[[:human genes:c:csnk2b|CSNK2B]]|0.416|
|[[:human genes:f:flvcr1|FLVCR1]]|0.415|
|[[:human genes:u:ube2k|UBE2K]]|0.414|
|[[:human genes:c:cox17|COX17]]|0.414|
|[[:human genes:t:trmt10a|TRMT10A]]|0.412|
|[[:human genes:c:c17orf89|C17orf89]]|0.411|
|[[:human genes:m:mars2|MARS2]]|0.411|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.411|
|[[:human genes:e:ears2|EARS2]]|0.41|
|[[:human genes:r:rpusd4|RPUSD4]]|0.409|
|[[:human genes:m:mrps2|MRPS2]]|0.409|
|[[:human genes:n:nae1|NAE1]]|0.408|
|[[:human genes:m:mrpl27|MRPL27]]|0.408|
|[[:human genes:a:atp5h|ATP5H]]|0.407|
|[[:human genes:a:alg2|ALG2]]|0.406|
|[[:human genes:s:serf2|SERF2]]|0.406|
|[[:human genes:w:wdr24|WDR24]]|0.406|
|[[:human genes:t:tmem41b|TMEM41B]]|0.405|
|[[:human genes:o:oraov1|ORAOV1]]|0.404|
|[[:human genes:t:taf1a|TAF1A]]|0.404|
|[[:human genes:s:selrc1|SELRC1]]|0.404|
|[[:human genes:u:uqcr10|UQCR10]]|0.403|
|[[:human genes:t:top3a|TOP3A]]|0.402|
|[[:human genes:c:cox7b|COX7B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 88/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|4/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|6/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1965
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPA2 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>