PPAP2A

Entrez Summary: N/A
UniProt Summary: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269|PubMed:12909631}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphingosine-1-phosphate phosphatase activity
germ cell migration
lipid phosphatase activity
phosphatidate phosphatase activity
protein kinase C-activating G protein-coupled receptor signaling pathway
phospholipid dephosphorylation
androgen receptor signaling pathway
phosphatase activity
intracellular steroid hormone receptor signaling pathway
sphingolipid biosynthetic process
steroid hormone mediated signaling pathway
membrane lipid biosynthetic process
sphingolipid metabolic process
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
lipid modification
membrane lipid metabolic process
protein dephosphorylation
dephosphorylation
response to steroid hormone
cellular process involved in reproduction in multicellular organism
phospholipid metabolic process
regulation of lipid metabolic process
cellular response to lipid
cellular response to organic cyclic compound
lipid biosynthetic process
cellular response to hormone stimulus
negative regulation of cell population proliferation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
response to lipid
organophosphate metabolic process
response to hormone
response to organic cyclic compound
cellular lipid metabolic process
cell migration
multi-organism reproductive process