PPAP2B [The Human Chemical-Genetic Interaction Map Project]

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======= PPAP2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLPP3
  * **<color #00a2e8>Official Name</color>**: phospholipid phosphatase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8613|8613]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14495|O14495]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPAP2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPAP2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|canonical Wnt signaling pathway involved in positive regulation of wound healing|
|canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion|
|canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration|
|sphingosine-1-phosphate phosphatase activity|
|germ cell migration|
|lipid phosphatase activity|
|phosphatidate phosphatase activity|
|phospholipid dephosphorylation|
|phosphoprotein phosphatase activity|
|phosphatase activity|
|positive regulation of wound healing|
|homotypic cell-cell adhesion|
|adherens junction|
|positive regulation of response to wounding|
|canonical Wnt signaling pathway|
|sphingolipid biosynthetic process|
|positive regulation of endothelial cell migration|
|membrane lipid biosynthetic process|
|regulation of wound healing|
|positive regulation of epithelial cell migration|
|sphingolipid metabolic process|
|regulation of endothelial cell migration|
|regulation of response to wounding|
|protein stabilization|
|lipid modification|
|membrane lipid metabolic process|
|protein dephosphorylation|
|regulation of epithelial cell migration|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|regulation of protein stability|
|dephosphorylation|
|cellular process involved in reproduction in multicellular organism|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|phospholipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|negative regulation of phosphorylation|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|lipid biosynthetic process|
|negative regulation of protein modification process|
|regulation of cell adhesion|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|organophosphate metabolic process|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|cell migration|
|regulation of locomotion|
|Golgi apparatus|
|multi-organism reproductive process|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|lipid metabolic process|
|locomotion|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.81|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11061
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPAP2B Expression in NALM6 Cells: 0.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>