PPAP2B

Entrez Summary: N/A
UniProt Summary: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.001μM R00 exp3	-1.81
MK-1775 0.32μM R02 exp75	2.21

canonical Wnt signaling pathway involved in positive regulation of wound healing
canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion
canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration
sphingosine-1-phosphate phosphatase activity
germ cell migration
lipid phosphatase activity
phosphatidate phosphatase activity
phospholipid dephosphorylation
phosphoprotein phosphatase activity
phosphatase activity
positive regulation of wound healing
homotypic cell-cell adhesion
adherens junction
positive regulation of response to wounding
canonical Wnt signaling pathway
sphingolipid biosynthetic process
positive regulation of endothelial cell migration
membrane lipid biosynthetic process
regulation of wound healing
positive regulation of epithelial cell migration
sphingolipid metabolic process
regulation of endothelial cell migration
regulation of response to wounding
protein stabilization
lipid modification
membrane lipid metabolic process
protein dephosphorylation
regulation of epithelial cell migration
positive regulation of cell-cell adhesion
positive regulation of DNA-binding transcription factor activity
regulation of protein stability
dephosphorylation
cellular process involved in reproduction in multicellular organism
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
phospholipid metabolic process
regulation of cell-cell adhesion
positive regulation of cell adhesion
negative regulation of protein phosphorylation