PPARD
Gene Information
- Official Symbol: PPARD
- Official Name: peroxisome proliferator activated receptor delta
- Aliases and Previous Symbols: N/A
- Entrez ID: 5467
- UniProt: Q03181
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Hormone recep |
| zf-C4 |
GO Terms
| linoleic acid binding |
| positive regulation of skeletal muscle tissue regeneration |
| keratinocyte migration |
| regulation of skeletal muscle tissue regeneration |
| negative regulation of cholesterol storage |
| positive regulation of myoblast proliferation |
| vitamin A metabolic process |
| negative regulation of collagen biosynthetic process |
| keratinocyte proliferation |
| negative regulation of collagen metabolic process |
| regulation of myoblast proliferation |
| negative regulation of pri-miRNA transcription by RNA polymerase II |
| regulation of skeletal muscle satellite cell proliferation |
| regulation of skeletal muscle cell proliferation |
| regulation of cholesterol storage |
| response to vitamin A |
| negative regulation of lipid storage |
| negative regulation of smooth muscle cell migration |
| fatty acid binding |
| decidualization |
| mRNA transcription |
| negative regulation of myoblast differentiation |
| NF-kappaB binding |
| glucose transmembrane transport |
| maternal placenta development |
| hexose transmembrane transport |
| RNA polymerase II repressing transcription factor binding |
| regulation of collagen biosynthetic process |
| adipose tissue development |
| fat-soluble vitamin metabolic process |
| monosaccharide transmembrane transport |
| embryo implantation |
| positive regulation of epidermis development |
| carbohydrate transmembrane transport |
| regulation of collagen metabolic process |
| negative regulation of lipid localization |
| regulation of pri-miRNA transcription by RNA polymerase II |
| regulation of lipid storage |
| negative regulation of smooth muscle cell proliferation |
| nuclear receptor activity |
| steroid hormone receptor activity |
| regulation of myoblast differentiation |
| positive regulation of wound healing |
| drug binding |
| positive regulation of blood vessel diameter |
| fatty acid beta-oxidation |
| regulation of smooth muscle cell migration |
| positive regulation of fat cell differentiation |
| maternal process involved in female pregnancy |
| positive regulation of response to wounding |
| response to activity |
| nuclear receptor transcription coactivator activity |
| RNA polymerase II transcription factor complex |
| positive regulation of insulin secretion |
| fatty acid transport |
| carbohydrate transport |
| transcription regulatory region sequence-specific DNA binding |
| fatty acid oxidation |
| lipid oxidation |
| epithelial cell migration |
| regulation of epidermis development |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| epithelium migration |
| response to vitamin |
| epithelial cell proliferation |
| proteoglycan metabolic process |
| tissue migration |
| fatty acid catabolic process |
| positive regulation of peptide hormone secretion |
| retinoid metabolic process |
| axon ensheathment |
| ensheathment of neurons |
| diterpenoid metabolic process |
| glucose metabolic process |
| cholesterol metabolic process |
| monocarboxylic acid catabolic process |
| regulation of phosphatidylinositol 3-kinase signaling |
| steroid hormone mediated signaling pathway |
| terpenoid metabolic process |
| regulation of fat cell differentiation |
| vitamin metabolic process |
| negative regulation of epithelial cell proliferation |
| positive regulation of hormone secretion |
| secondary alcohol metabolic process |
| regulation of smooth muscle cell proliferation |
| sterol metabolic process |
| monocarboxylic acid transport |
| negative regulation of inflammatory response |
| regulation of lipid localization |
| regulation of wound healing |
| response to glucose |
| isoprenoid metabolic process |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| response to hexose |
| response to monosaccharide |
| placenta development |
| lipid binding |
| hexose metabolic process |
| intracellular receptor signaling pathway |
| regulation of response to wounding |
| vascular process in circulatory system |
| hormone-mediated signaling pathway |
| positive regulation of developmental growth |
| ameboidal-type cell migration |
| response to carbohydrate |
| transcription initiation from RNA polymerase II promoter |
| regulation of insulin secretion |
| female pregnancy |
| negative regulation of cell growth |
| cell-substrate adhesion |
| cellular response to lipopolysaccharide |
| cellular response to steroid hormone stimulus |
| cellular response to hypoxia |
| cellular response to molecule of bacterial origin |
| cellular lipid catabolic process |
| cellular response to decreased oxygen levels |
| monosaccharide metabolic process |
| lipid modification |
| signaling receptor activity |
| negative regulation of defense response |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| cellular response to oxygen levels |
| cellular response to biotic stimulus |
| response to nutrient |
| DNA-templated transcription, initiation |
| connective tissue development |
| nuclear chromatin |
| negative regulation of growth |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| phospholipid biosynthetic process |
| negative regulation of cell migration |
| positive regulation of growth |
| steroid metabolic process |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| negative regulation of cell motility |
| apoptotic signaling pathway |
| positive regulation of peptide secretion |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| lipid catabolic process |
| negative regulation of cellular component movement |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| response to lipopolysaccharide |
| alcohol metabolic process |
| lipid localization |
| negative regulation of locomotion |
| fatty acid metabolic process |
| response to molecule of bacterial origin |
| response to steroid hormone |
| regulation of developmental growth |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| response to hypoxia |
| response to decreased oxygen levels |
| negative regulation of response to external stimulus |
| phospholipid metabolic process |
| response to oxygen levels |
| glycoprotein metabolic process |
| blood circulation |
| circulatory system process |
| regulation of lipid metabolic process |
| positive regulation of secretion by cell |
| regulation of cell growth |
| generation of precursor metabolites and energy |
| reproductive structure development |
| positive regulation of protein transport |
| reproductive system development |
| positive regulation of secretion |
| small molecule catabolic process |
| organic hydroxy compound metabolic process |
| organic anion transport |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| carbohydrate metabolic process |
| wound healing |
| transcription by RNA polymerase II |
| protein heterodimerization activity |
| regulation of peptide secretion |
| response to nutrient levels |
| regulation of anatomical structure size |
| cellular response to lipid |
| heart development |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| regulation of hormone levels |
| organophosphate biosynthetic process |
| cellular response to organic cyclic compound |
| cell population proliferation |
| response to wounding |
| lipid biosynthetic process |
| anion transport |
| cellular response to hormone stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| developmental process involved in reproduction |
| regulation of growth |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| response to bacterium |
| mRNA metabolic process |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| multicellular organismal reproductive process |
| zinc ion binding |
| multicellular organism reproduction |
| regulation of cell migration |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| apoptotic process |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| cellular lipid metabolic process |
| oxidation-reduction process |
| cell migration |
| positive regulation of cell differentiation |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| multi-organism reproductive process |
| regulation of cellular component movement |
| oxoacid metabolic process |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| localization of cell |
| cell motility |
| cell death |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| transmembrane transport |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4162
- Expression level (log2 read counts): 4.65
Expression Distribution
PPARD Expression in NALM6 Cells: 4.65
