PPARG [The Human Chemical-Genetic Interaction Map Project]

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======= PPARG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPARG
  * **<color #00a2e8>Official Name</color>**: peroxisome proliferator activated receptor gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5468|5468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37231|P37231]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPARG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPARG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601487|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PPARgamma N|
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|low-density lipoprotein particle receptor biosynthetic process|
|prostaglandin receptor activity|
|negative regulation of pancreatic stellate cell proliferation|
|response to metformin|
|regulation of cholesterol transporter activity|
|cellular response to vitamin E|
|regulation of pancreatic stellate cell proliferation|
|regulation of lipid transporter activity|
|DBD domain binding|
|negative regulation of vascular endothelial cell proliferation|
|arachidonic acid binding|
|negative regulation of sequestering of triglyceride|
|receptor biosynthetic process|
|negative regulation of receptor biosynthetic process|
|foam cell differentiation|
|negative regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of response to interferon-gamma|
|LBD domain binding|
|peroxisome proliferator activated receptor signaling pathway|
|positive regulation of vascular associated smooth muscle cell apoptotic process|
|macrophage derived foam cell differentiation|
|cellular response to hyperoxia|
|pri-miRNA transcription by RNA polymerase II|
|negative regulation of cholesterol storage|
|regulation of vascular associated smooth muscle cell apoptotic process|
|negative regulation of collagen biosynthetic process|
|negative regulation of collagen metabolic process|
|low-density lipoprotein receptor particle metabolic process|
|response to vitamin E|
|lipoprotein localization|
|negative regulation of acute inflammatory response|
|negative regulation of telomerase activity|
|regulation of sequestering of triglyceride|
|lipoprotein transport|
|positive regulation of membrane invagination|
|positive regulation of phagocytosis, engulfment|
|negative regulation of macrophage derived foam cell differentiation|
|white fat cell differentiation|
|cellular response to increased oxygen levels|
|negative regulation of gene silencing by miRNA|
|regulation of cholesterol storage|
|regulation of phagocytosis, engulfment|
|positive regulation of smooth muscle cell apoptotic process|
|positive regulation of fatty acid oxidation|
|regulation of membrane invagination|
|cellular response to prostaglandin E stimulus|
|negative regulation of gene silencing by RNA|
|negative regulation of posttranscriptional gene silencing|
|response to caffeine|
|response to diuretic|
|regulation of transcription involved in cell fate commitment|
|alpha-actinin binding|
|mononuclear cell differentiation|
|monocyte differentiation|
|retinoid X receptor binding|
|cellular response to low-density lipoprotein particle stimulus|
|negative regulation of vascular smooth muscle cell proliferation|
|response to vitamin A|
|regulation of vascular endothelial cell proliferation|
|negative regulation of lipid storage|
|response to hyperoxia|
|cellular response to prostaglandin stimulus|
|regulation of receptor biosynthetic process|
|response to prostaglandin E|
|fatty acid binding|
|positive regulation of oligodendrocyte differentiation|
|cellular response to vitamin|
|regulation of smooth muscle cell apoptotic process|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|response to immobilization stress|
|response to lipoprotein particle|
|response to increased oxygen levels|
|positive regulation of muscle cell apoptotic process|
|negative regulation of fibroblast proliferation|
|regulation of macrophage derived foam cell differentiation|
|cellular response to lipoprotein particle stimulus|
|regulation of fatty acid oxidation|
|response to prostaglandin|
|negative regulation of blood vessel endothelial cell migration|
|activating transcription factor binding|
|positive regulation of fatty acid metabolic process|
|RNA polymerase II repressing transcription factor binding|
|regulation of collagen biosynthetic process|
|negative regulation of gene silencing|
|negative regulation of endothelial cell proliferation|
|negative regulation of DNA biosynthetic process|
|regulation of oligodendrocyte differentiation|
|regulation of collagen metabolic process|
|negative regulation of lipid localization|
|positive regulation of glial cell differentiation|
|estrogen receptor binding|
|regulation of acute inflammatory response|
|regulation of lipid storage|
|negative regulation of smooth muscle cell proliferation|
|regulation of sterol transport|
|nuclear receptor activity|
|negative regulation of endothelial cell migration|
|response to cold|
|E-box binding|
|regulation of vascular smooth muscle cell proliferation|
|regulation of telomerase activity|
|peptide binding|
|steroid hormone receptor activity|
|cellular response to fatty acid|
|positive regulation of DNA binding|
|negative regulation of innate immune response|
|protein self-association|
|drug binding|
|long-chain fatty acid transport|
|positive regulation of fat cell differentiation|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|nuclear receptor transcription coactivator activity|
|negative regulation of epithelial cell migration|
|cellular response to nutrient|
|regulation of muscle cell apoptotic process|
|positive regulation of phagocytosis|
|cellular response to retinoic acid|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|RNA polymerase II transcription factor complex|
|fatty acid transport|
|animal organ regeneration|
|response to estrogen|
|transcription regulatory region sequence-specific DNA binding|
|fatty acid oxidation|
|lipid oxidation|
|regulation of fibroblast proliferation|
|cellular response to alcohol|
|response to fatty acid|
|protein phosphatase binding|
|response to vitamin|
|regulation of fatty acid metabolic process|
|regulation of gene silencing by miRNA|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of posttranscriptional gene silencing|
|regulation of blood vessel endothelial cell migration|
|regulation of gene silencing by RNA|
|cellular response to ketone|
|negative regulation of response to biotic stimulus|
|regulation of phagocytosis|
|positive regulation of endocytosis|
|double-stranded DNA binding|
|negative regulation of angiogenesis|
|receptor metabolic process|
|negative regulation of blood vessel morphogenesis|
|fat cell differentiation|
|regulation of lipid transport|
|response to retinoic acid|
|myeloid leukocyte differentiation|
|response to alkaloid|
|regulation of DNA biosynthetic process|
|regulation of circadian rhythm|
|regulation of gliogenesis|
|negative regulation of vasculature development|
|steroid hormone mediated signaling pathway|
|negative regulation of DNA metabolic process|
|regulation of fat cell differentiation|
|negative regulation of epithelial cell proliferation|
|regulation of DNA binding|
|regulation of endothelial cell proliferation|
|regulation of gene silencing|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of smooth muscle cell proliferation|
|lipid homeostasis|
|negative regulation of inflammatory response|
|monocarboxylic acid transport|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|negative regulation of immune response|
|positive regulation of cysteine-type endopeptidase activity|
|placenta development|
|response to purine-containing compound|
|lipid binding|
|regeneration|
|regulation of endothelial cell migration|
|cell maturation|
|cellular response to insulin stimulus|
|regulation of cytokine-mediated signaling pathway|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|positive regulation of endopeptidase activity|
|regulation of response to cytokine stimulus|
|transcription initiation from RNA polymerase II promoter|
|response to temperature stimulus|
|positive regulation of binding|
|regulation of blood pressure|
|negative regulation of cell growth|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|positive regulation of peptidase activity|
|response to starvation|
|response to ketone|
|lipid modification|
|signaling receptor activity|
|regulation of endocytosis|
|negative regulation of defense response|
|cellular response to acid chemical|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to nutrient|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|regulation of epithelial cell migration|
|myeloid cell differentiation|
|response to insulin|
|response to alcohol|
|cellular response to nutrient levels|
|developmental maturation|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|rhythmic process|
|regulation of transporter activity|
|regulation of angiogenesis|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|response to xenobiotic stimulus|
|negative regulation of cellular component movement|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|lipid localization|
|regulation of vasculature development|
|negative regulation of locomotion|
|fatty acid metabolic process|
|cellular response to peptide|
|response to steroid hormone|
|leukocyte differentiation|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|regulation of inflammatory response|
|response to acid chemical|
|enzyme binding|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|regulation of binding|
|response to oxygen levels|
|blood circulation|
|response to peptide hormone|
|chromatin binding|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of endopeptidase activity|
|regulation of cell growth|
|sequence-specific DNA binding|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|reproductive system development|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of innate immune response|
|organic anion transport|
|positive regulation of neurogenesis|
|response to peptide|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|response to nutrient levels|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|heart development|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|anion transport|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|epithelium development|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPARG Expression in NALM6 Cells: -0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>