PPBP

Entrez Summary: N/A
UniProt Summary: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Milciclib 2μM R08 exp502	-1.78
UM0011500 10μM R05 exp246	1.77

glucose transmembrane transporter activity
glucose transmembrane transport
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
chemokine activity
tertiary granule lumen
antimicrobial humoral immune response mediated by antimicrobial peptide
platelet alpha granule lumen
carbohydrate transport
chemokine-mediated signaling pathway
neutrophil chemotaxis
positive regulation of cell division
granulocyte chemotaxis
cellular response to chemokine
response to chemokine
neutrophil migration
granulocyte migration
antimicrobial humoral response
myeloid leukocyte migration
platelet degranulation
leukocyte chemotaxis
growth factor activity
regulation of cell division
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cell chemotaxis
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium
humoral immune response
leukocyte migration
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
inflammatory response
neutrophil activation
granulocyte activation
leukocyte degranulation