PPCS [The Human Chemical-Genetic Interaction Map Project]

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======= PPCS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPCS
  * **<color #00a2e8>Official Name</color>**: phosphopantothenoylcysteine synthetase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79717|79717]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAB8|Q9HAB8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPCS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPCS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609853|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:12906824}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DFP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphopantothenate--cysteine ligase activity|
|coenzyme A biosynthetic process|
|acetyl-CoA biosynthetic process|
|coenzyme A metabolic process|
|acetyl-CoA metabolic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|heart process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|circulatory system process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|amide biosynthetic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.68|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.31|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.12|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.96|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.94|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.79|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.77|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.7|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.74|
|[[:results:exp539|42°C R08 exp539]]|1.88|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.662|
|[[:human genes:a:atxn10|ATXN10]]|0.612|
|[[:human genes:d:dohh|DOHH]]|0.604|
|[[:human genes:d:dpagt1|DPAGT1]]|0.584|
|[[:human genes:t:trmt61a|TRMT61A]]|0.578|
|[[:human genes:v:vezt|VEZT]]|0.575|
|[[:human genes:t:ten1|TEN1]]|0.574|
|[[:human genes:g:gemin6|GEMIN6]]|0.573|
|[[:human genes:a:alg1|ALG1]]|0.572|
|[[:human genes:u:uap1|UAP1]]|0.567|
|[[:human genes:r:rpia|RPIA]]|0.564|
|[[:human genes:d:dnlz|DNLZ]]|0.561|
|[[:human genes:p:pmm2|PMM2]]|0.547|
|[[:human genes:u:uhrf1|UHRF1]]|0.547|
|[[:human genes:r:rtcb|RTCB]]|0.544|
|[[:human genes:r:rft1|RFT1]]|0.543|
|[[:human genes:s:slc25a26|SLC25A26]]|0.54|
|[[:human genes:p:ppcdc|PPCDC]]|0.539|
|[[:human genes:t:triap1|TRIAP1]]|0.538|
|[[:human genes:g:gemin8|GEMIN8]]|0.537|
|[[:human genes:f:fh|FH]]|0.537|
|[[:human genes:s:srp14|SRP14]]|0.533|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.531|
|[[:human genes:r:rpp21|RPP21]]|0.525|
|[[:human genes:g:gfpt1|GFPT1]]|0.522|
|[[:human genes:d:dhrsx|DHRSX]]|0.52|
|[[:human genes:a:atic|ATIC]]|0.52|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.519|
|[[:human genes:d:dhps|DHPS]]|0.514|
|[[:human genes:t:tpk1|TPK1]]|0.512|
|[[:human genes:y:yars2|YARS2]]|0.511|
|[[:human genes:a:alg13|ALG13]]|0.508|
|[[:human genes:t:ttc4|TTC4]]|0.507|
|[[:human genes:c:c15orf41|C15orf41]]|0.507|
|[[:human genes:r:rptor|RPTOR]]|0.506|
|[[:human genes:t:trnt1|TRNT1]]|0.504|
|[[:human genes:r:rabggtb|RABGGTB]]|0.501|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.499|
|[[:human genes:n:nbn|NBN]]|0.499|
|[[:human genes:p:pgm3|PGM3]]|0.498|
|[[:human genes:z:zrsr2|ZRSR2]]|0.497|
|[[:human genes:r:romo1|ROMO1]]|0.496|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.492|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.49|
|[[:human genes:e:exoc4|EXOC4]]|0.489|
|[[:human genes:s:srd5a3|SRD5A3]]|0.489|
|[[:human genes:p:ppp6c|PPP6C]]|0.488|
|[[:human genes:l:lsm10|LSM10]]|0.488|
|[[:human genes:s:sars2|SARS2]]|0.485|
|[[:human genes:a:adsl|ADSL]]|0.483|
|[[:human genes:r:rnmt|RNMT]]|0.482|
|[[:human genes:g:gmppb|GMPPB]]|0.482|
|[[:human genes:t:taz|TAZ]]|0.48|
|[[:human genes:u:utp23|UTP23]]|0.478|
|[[:human genes:m:mrpl21|MRPL21]]|0.477|
|[[:human genes:d:dap3|DAP3]]|0.476|
|[[:human genes:f:fen1|FEN1]]|0.475|
|[[:human genes:c:cep57|CEP57]]|0.474|
|[[:human genes:m:mbtps2|MBTPS2]]|0.473|
|[[:human genes:d:dars2|DARS2]]|0.472|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.472|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.472|
|[[:human genes:p:ppa2|PPA2]]|0.471|
|[[:human genes:e:elac2|ELAC2]]|0.471|
|[[:human genes:n:nae1|NAE1]]|0.47|
|[[:human genes:d:dr1|DR1]]|0.469|
|[[:human genes:c:chchd4|CHCHD4]]|0.469|
|[[:human genes:g:gemin7|GEMIN7]]|0.468|
|[[:human genes:g:gnb1l|GNB1L]]|0.468|
|[[:human genes:s:slc25a19|SLC25A19]]|0.466|
|[[:human genes:t:tamm41|TAMM41]]|0.466|
|[[:human genes:r:rpe|RPE]]|0.464|
|[[:human genes:m:mrps34|MRPS34]]|0.463|
|[[:human genes:h:hccs|HCCS]]|0.46|
|[[:human genes:x:xrcc2|XRCC2]]|0.46|
|[[:human genes:t:trmt10a|TRMT10A]]|0.46|
|[[:human genes:l:lsm11|LSM11]]|0.459|
|[[:human genes:m:msto1|MSTO1]]|0.459|
|[[:human genes:b:bcs1l|BCS1L]]|0.458|
|[[:human genes:s:ssb|SSB]]|0.457|
|[[:human genes:d:dolk|DOLK]]|0.457|
|[[:human genes:p:pmvk|PMVK]]|0.455|
|[[:human genes:t:tsen34|TSEN34]]|0.454|
|[[:human genes:m:mrpl23|MRPL23]]|0.452|
|[[:human genes:c:c1d|C1D]]|0.451|
|[[:human genes:e:eef1e1|EEF1E1]]|0.451|
|[[:human genes:d:ddx39a|DDX39A]]|0.451|
|[[:human genes:m:mrps14|MRPS14]]|0.449|
|[[:human genes:r:rpusd4|RPUSD4]]|0.449|
|[[:human genes:m:mrps5|MRPS5]]|0.446|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.446|
|[[:human genes:t:tsen54|TSEN54]]|0.445|
|[[:human genes:d:ddx20|DDX20]]|0.445|
|[[:human genes:t:tufm|TUFM]]|0.444|
|[[:human genes:c:cox16|COX16]]|0.444|
|[[:human genes:c:cbfb|CBFB]]|0.444|
|[[:human genes:t:tmem41b|TMEM41B]]|0.442|
|[[:human genes:u:uxt|UXT]]|0.442|
|[[:human genes:t:tmem242|TMEM242]]|0.442|
|[[:human genes:t:trmt5|TRMT5]]|0.439|
|[[:human genes:o:oraov1|ORAOV1]]|0.438|
|[[:human genes:t:trmt6|TRMT6]]|0.436|
|[[:human genes:p:pars2|PARS2]]|0.435|
|[[:human genes:c:crls1|CRLS1]]|0.434|
|[[:human genes:p:ptar1|PTAR1]]|0.433|
|[[:human genes:w:wdr82|WDR82]]|0.429|
|[[:human genes:p:pgs1|PGS1]]|0.429|
|[[:human genes:m:mrps18a|MRPS18A]]|0.428|
|[[:human genes:f:fnta|FNTA]]|0.427|
|[[:human genes:m:mrpl36|MRPL36]]|0.427|
|[[:human genes:m:mrps11|MRPS11]]|0.426|
|[[:human genes:a:alg6|ALG6]]|0.426|
|[[:human genes:b:bap1|BAP1]]|0.426|
|[[:human genes:t:tars2|TARS2]]|0.426|
|[[:human genes:t:timm10|TIMM10]]|0.425|
|[[:human genes:p:pggt1b|PGGT1B]]|0.425|
|[[:human genes:r:rfk|RFK]]|0.424|
|[[:human genes:e:elp2|ELP2]]|0.423|
|[[:human genes:p:ppp4c|PPP4C]]|0.423|
|[[:human genes:c:cxorf56|CXorf56]]|0.423|
|[[:human genes:a:atp5a1|ATP5A1]]|0.423|
|[[:human genes:s:sco2|SCO2]]|0.423|
|[[:human genes:b:bak1|BAK1]]|0.422|
|[[:human genes:m:mrps2|MRPS2]]|0.421|
|[[:human genes:c:ctc1|CTC1]]|0.42|
|[[:human genes:m:mis18a|MIS18A]]|0.419|
|[[:human genes:m:mrps6|MRPS6]]|0.418|
|[[:human genes:m:mrps16|MRPS16]]|0.418|
|[[:human genes:v:vars2|VARS2]]|0.417|
|[[:human genes:m:mrps33|MRPS33]]|0.417|
|[[:human genes:p:pelo|PELO]]|0.417|
|[[:human genes:t:tomm20|TOMM20]]|0.417|
|[[:human genes:m:mrps21|MRPS21]]|0.416|
|[[:human genes:p:polr3h|POLR3H]]|0.415|
|[[:human genes:p:pdss1|PDSS1]]|0.415|
|[[:human genes:s:selrc1|SELRC1]]|0.414|
|[[:human genes:a:alg2|ALG2]]|0.414|
|[[:human genes:a:atp2a2|ATP2A2]]|0.413|
|[[:human genes:n:n6amt1|N6AMT1]]|0.413|
|[[:human genes:a:alg5|ALG5]]|0.413|
|[[:human genes:e:eif3f|EIF3F]]|0.412|
|[[:human genes:m:mrpl15|MRPL15]]|0.412|
|[[:human genes:u:uba3|UBA3]]|0.412|
|[[:human genes:t:tpi1|TPI1]]|0.411|
|[[:human genes:d:ddx55|DDX55]]|0.411|
|[[:human genes:t:txnl4b|TXNL4B]]|0.411|
|[[:human genes:a:atp5b|ATP5B]]|0.41|
|[[:human genes:t:tkt|TKT]]|0.41|
|[[:human genes:g:gemin4|GEMIN4]]|0.41|
|[[:human genes:o:osgep|OSGEP]]|0.41|
|[[:human genes:h:hars2|HARS2]]|0.409|
|[[:human genes:s:srprb|SRPRB]]|0.408|
|[[:human genes:t:taf1a|TAF1A]]|0.407|
|[[:human genes:t:tbcb|TBCB]]|0.407|
|[[:human genes:e:elp3|ELP3]]|0.406|
|[[:human genes:u:uqcr10|UQCR10]]|0.406|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.403|
|[[:human genes:d:ddx1|DDX1]]|0.403|
|[[:human genes:a:atp5j|ATP5J]]|0.402|
|[[:human genes:g:gtf3a|GTF3A]]|0.402|
|[[:human genes:s:snapc5|SNAPC5]]|0.402|
|[[:human genes:m:mocs3|MOCS3]]|0.401|
|[[:human genes:m:mrp63|MRP63]]|0.401|
|[[:human genes:s:sec61g|SEC61G]]|0.401|
|[[:human genes:z:znhit1|ZNHIT1]]|0.401|
|[[:human genes:t:tbca|TBCA]]|0.401|
|[[:human genes:t:tprkb|TPRKB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1811
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPCS Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>