PPCS

Gene Information

Official Symbol: PPCS
Official Name: phosphopantothenoylcysteine synthetase
Aliases and Previous Symbols: N/A
Entrez ID: 79717
UniProt: Q9HAB8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:12906824}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Temozolomide 200μM R04 exp189	-2.68
Chloroquine 32μM R08 exp470	-2.31
MSC2530818 10μM R07 exp379	-2.12
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.96
Isonicotinamide 500μM R03 exp129	-1.94
RO-3306 3 to 4μM on day4 R04 exp165	-1.79
Fluvastatin 2.2μM R06 exp282	-1.77
BI-2536 0.02μM R03 exp96	1.7
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.74
42°C R08 exp539	1.88
Deferoxamine 11μM R07 exp350	2.03
Aphidicolin 0.4μM R08 exp440	2.28

Gene	Correlation
THG1L	0.662
ATXN10	0.612
DOHH	0.604
DPAGT1	0.584
TRMT61A	0.578
VEZT	0.575
TEN1	0.574
GEMIN6	0.573
ALG1	0.572
UAP1	0.567
RPIA	0.564
DNLZ	0.561
PMM2	0.547
UHRF1	0.547
RTCB	0.544
RFT1	0.543
SLC25A26	0.54
PPCDC	0.539
TRIAP1	0.538
GEMIN8	0.537
FH	0.537
SRP14	0.533
GTF3C3	0.531
RPP21	0.525
GFPT1	0.522
DHRSX	0.52
ATIC	0.52
SUPV3L1	0.519
DHPS	0.514
TPK1	0.512
YARS2	0.511
ALG13	0.508
TTC4	0.507
C15orf41	0.507
RPTOR	0.506
TRNT1	0.504
RABGGTB	0.501
GTF3C6	0.499
NBN	0.499
PGM3	0.498
ZRSR2	0.497
ROMO1	0.496
AASDHPPT	0.492
HSD17B10	0.49
EXOC4	0.489
SRD5A3	0.489
PPP6C	0.488
LSM10	0.488
SARS2	0.485
ADSL	0.483
RNMT	0.482
GMPPB	0.482
TAZ	0.48
UTP23	0.478
MRPL21	0.477
DAP3	0.476
FEN1	0.475
CEP57	0.474
MBTPS2	0.473
DARS2	0.472
KIAA0391	0.472
GTF3C4	0.472
PPA2	0.471
ELAC2	0.471
NAE1	0.47
DR1	0.469
CHCHD4	0.469
GEMIN7	0.468
GNB1L	0.468
SLC25A19	0.466
TAMM41	0.466
RPE	0.464
MRPS34	0.463
HCCS	0.46
XRCC2	0.46
TRMT10A	0.46
LSM11	0.459
MSTO1	0.459
BCS1L	0.458
SSB	0.457
DOLK	0.457
PMVK	0.455
TSEN34	0.454
MRPL23	0.452
C1D	0.451
EEF1E1	0.451
DDX39A	0.451
MRPS14	0.449
RPUSD4	0.449
MRPS5	0.446
UQCRC2	0.446
TSEN54	0.445
DDX20	0.445
TUFM	0.444
COX16	0.444
CBFB	0.444
TMEM41B	0.442
UXT	0.442
TMEM242	0.442
TRMT5	0.439
ORAOV1	0.438
TRMT6	0.436
PARS2	0.435
CRLS1	0.434
PTAR1	0.433
WDR82	0.429
PGS1	0.429
MRPS18A	0.428
FNTA	0.427
MRPL36	0.427
MRPS11	0.426
ALG6	0.426
BAP1	0.426
TARS2	0.426
TIMM10	0.425
PGGT1B	0.425
RFK	0.424
ELP2	0.423
PPP4C	0.423
CXorf56	0.423
ATP5A1	0.423
SCO2	0.423
BAK1	0.422
MRPS2	0.421
CTC1	0.42
MIS18A	0.419
MRPS6	0.418
MRPS16	0.418
VARS2	0.417
MRPS33	0.417
PELO	0.417
TOMM20	0.417
MRPS21	0.416
POLR3H	0.415
PDSS1	0.415
SELRC1	0.414
ALG2	0.414
ATP2A2	0.413
N6AMT1	0.413
ALG5	0.413
EIF3F	0.412
MRPL15	0.412
UBA3	0.412
TPI1	0.411
DDX55	0.411
TXNL4B	0.411
ATP5B	0.41
TKT	0.41
GEMIN4	0.41
OSGEP	0.41
HARS2	0.409
SRPRB	0.408
TAF1A	0.407
TBCB	0.407
ELP3	0.406
UQCR10	0.406
RNASEH1	0.403
DDX1	0.403
ATP5J	0.402
GTF3A	0.402
SNAPC5	0.402
MOCS3	0.401
MRP63	0.401
SEC61G	0.401
ZNHIT1	0.401
TBCA	0.401
TPRKB	0.4

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1811
Expression level (log2 read counts): 4.56

Expression Distribution

phosphopantothenate–cysteine ligase activity
coenzyme A biosynthetic process
acetyl-CoA biosynthetic process
coenzyme A metabolic process
acetyl-CoA metabolic process
thioester biosynthetic process
acyl-CoA biosynthetic process
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
acyl-CoA metabolic process
thioester metabolic process
heart process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
circulatory system process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
amide biosynthetic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process