PPM1B [The Human Chemical-Genetic Interaction Map Project]

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======= PPM1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPM1B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase, Mg2+/Mn2+ dependent 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5495|5495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75688|O75688]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPM1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPM1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP2C C|
|PP2C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein myristoylation|
|N-terminal protein myristoylation|
|N-terminal protein lipidation|
|negative regulation of interferon-beta production|
|peptidyl-threonine dephosphorylation|
|magnesium-dependent protein serine/threonine phosphatase activity|
|negative regulation of NIK/NF-kappaB signaling|
|negative regulation of defense response to virus|
|N-terminal protein amino acid modification|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|manganese ion binding|
|protein serine/threonine phosphatase activity|
|regulation of defense response to virus|
|protein lipidation|
|lipoprotein biosynthetic process|
|negative regulation of response to biotic stimulus|
|regulation of NIK/NF-kappaB signaling|
|lipoprotein metabolic process|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|protein acylation|
|negative regulation of defense response|
|protein dephosphorylation|
|magnesium ion binding|
|negative regulation of multi-organism process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of cytokine production|
|dephosphorylation|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|regulation of cytokine production|
|regulation of defense response|
|regulation of multi-organism process|
|nucleolus|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.95|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.7|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.76|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.06|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15987
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPM1B Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>