PPM1B

Gene Information

Official Symbol: PPM1B
Official Name: protein phosphatase, Mg2+/Mn2+ dependent 1B
Aliases and Previous Symbols: N/A
Entrez ID: 5495
UniProt: O75688
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008].
UniProt Summary: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 4.1μM R02 exp72	-1.95
2-Methoxyestradiol 0.2μM R01 exp40	1.7
Rapamycin 0.001μM R08 exp429	1.7
Bafilomycin-A1 0.009μM R08 exp454	1.76
EPZ-5676 30μM R05 exp233	2.06
Doxycycline 10μM R00 exp18	2.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15987
Expression level (log2 read counts): 5.77

Expression Distribution

PP2C C
PP2C

protein myristoylation
N-terminal protein myristoylation
N-terminal protein lipidation
negative regulation of interferon-beta production
peptidyl-threonine dephosphorylation
magnesium-dependent protein serine/threonine phosphatase activity
negative regulation of NIK/NF-kappaB signaling
negative regulation of defense response to virus
N-terminal protein amino acid modification
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of type I interferon production
regulation of interferon-beta production
manganese ion binding
protein serine/threonine phosphatase activity
regulation of defense response to virus
protein lipidation
lipoprotein biosynthetic process
negative regulation of response to biotic stimulus
regulation of NIK/NF-kappaB signaling
lipoprotein metabolic process
negative regulation of immune effector process
regulation of type I interferon production
protein acylation
negative regulation of defense response
protein dephosphorylation
magnesium ion binding
negative regulation of multi-organism process
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of cytokine production
dephosphorylation
negative regulation of response to external stimulus
negative regulation of immune system process
regulation of immune effector process
negative regulation of intracellular signal transduction
regulation of response to biotic stimulus
regulation of cytokine production
regulation of defense response
regulation of multi-organism process
nucleolus
regulation of response to external stimulus