PPM1L

Entrez Summary: N/A
UniProt Summary: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:17456047}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

magnesium-dependent protein serine/threonine phosphatase activity
protein serine/threonine phosphatase activity
sphingolipid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
transmembrane receptor protein serine/threonine kinase signaling pathway
membrane lipid metabolic process
protein dephosphorylation
dephosphorylation
MAPK cascade
signal transduction by protein phosphorylation
lipid biosynthetic process
enzyme linked receptor protein signaling pathway
endoplasmic reticulum membrane
cellular lipid metabolic process
protein phosphorylation
lipid metabolic process
phosphorylation
organonitrogen compound biosynthetic process
intracellular signal transduction