PPME1 [The Human Chemical-Genetic Interaction Map Project]

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======= PPME1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPME1
  * **<color #00a2e8>Official Name</color>**: protein phosphatase methylesterase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51400|51400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y570|Q9Y570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPME1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPME1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611117|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 6|
|Abhydrolase 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein C-terminal methylesterase activity|
|protein demethylation|
|protein dealkylation|
|protein phosphatase 2A binding|
|protein phosphatase regulator activity|
|protein phosphatase inhibitor activity|
|negative regulation of phosphoprotein phosphatase activity|
|demethylation|
|negative regulation of protein dephosphorylation|
|protein phosphatase binding|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cadherin binding|
|negative regulation of hydrolase activity|
|protein kinase binding|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|mitotic cell cycle|
|negative regulation of catalytic activity|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|cell cycle|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-3.55|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.72|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.68|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.4|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.29|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.28|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.23|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.12|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.03|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.97|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.95|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.87|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.85|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.82|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.82|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.8|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.74|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.72|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.71|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.71|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.71|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.99|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.47|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|3.24|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.41|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|3.6|
|[[:results:exp59|UMK57 1μM R01 exp59]]|4.11|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|4.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lcmt1|LCMT1]]|0.656|
|[[:human genes:p:ppp2r4|PPP2R4]]|0.583|
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.575|
|[[:human genes:t:tiprl|TIPRL]]|0.559|
|[[:human genes:p:ppp2r5c|PPP2R5C]]|0.427|
|[[:human genes:c:cyb5r4|CYB5R4]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPME1 Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>