PPME1

Entrez Summary: N/A
UniProt Summary: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ETC-159 50μM R08 exp480	-3.55
Lead acetate 990μM R08 exp496	-2.72
Taxol 0.004μM R03 exp103	-2.68
Sulforaphane 9μM R08 exp526 no dilution day6	-2.4
MK-1775 0.32μM R02 exp75	-2.29
Arsenate 40μM R06 exp264	-2.28
Vincristine 0.0005μM R04 exp190	-2.23
Sulforaphane 9μM R08 exp525	-2.12
GSK461364A 0.005μM R03 exp125	-2.03
Docetaxel 0.002μM R01 exp45	-1.97
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.95
YM155 0.001μM R08 exp432	-1.87
Cytochalasin-B 5μM R07 exp349	-1.85
Rifampicin 30μM R08 exp430	-1.82
Trimetrexate 0.03μM R08 exp535	-1.82
Vinblastine 0.002μM R01 exp60	-1.8
THZ531 0.225μM R08 exp444	-1.74
Epigallocatechin gallate 20μM R05 exp230	-1.72
AICAR 240μM R03 exp116	-1.71
RS-1 10μM R08 exp519	-1.71
Nicotinate 1000μM R03 exp140	1.71
PU-H71 1μM R08 exp515	1.99
HMS-I1 1μM R01 exp46	2.47
Mdivi-1 15μM R05 exp217	3.24
Milciclib 2μM R08 exp502	3.41
BVD-523 15μM R02 exp67	3.6
UMK57 1μM R01 exp59	4.11
RO-3307 4.7μM R02 exp80	4.99

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Expression Distribution

Abhydrolase 6
Abhydrolase 5

protein C-terminal methylesterase activity
protein demethylation
protein dealkylation
protein phosphatase 2A binding
protein phosphatase regulator activity
protein phosphatase inhibitor activity
negative regulation of phosphoprotein phosphatase activity
demethylation
negative regulation of protein dephosphorylation
protein phosphatase binding
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
mitotic cell cycle phase transition
cell cycle phase transition
cadherin binding
negative regulation of hydrolase activity
protein kinase binding
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
mitotic cell cycle process
mitotic cell cycle
negative regulation of catalytic activity
cell cycle process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
cell cycle
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process