PPOX [The Human Chemical-Genetic Interaction Map Project]

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======= PPOX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPOX
  * **<color #00a2e8>Official Name</color>**: protoporphyrinogen oxidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5498|5498]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50336|P50336]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPOX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPOX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600923|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. {ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411, ECO:0000269|PubMed:7713909}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amino oxidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic component of mitochondrial inner membrane|
|oxygen-dependent protoporphyrinogen oxidase activity|
|protoporphyrinogen IX biosynthetic process|
|protoporphyrinogen IX metabolic process|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|integral component of mitochondrial inner membrane|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|flavin adenine dinucleotide binding|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|mitochondrial intermembrane space|
|mitochondrial membrane|
|oxidoreductase activity|
|cofactor biosynthetic process|
|cofactor metabolic process|
|oxidation-reduction process|
|response to drug|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.88|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.01|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|8.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alad|ALAD]]|0.519|
|[[:human genes:h:hmbs|HMBS]]|0.46|
|[[:human genes:c:cpox|CPOX]]|0.441|
|[[:human genes:f:fech|FECH]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2963
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPOX Expression in NALM6 Cells: 3.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>