PPOX
Gene Information
- Official Symbol: PPOX
- Official Name: protoporphyrinogen oxidase
- Aliases and Previous Symbols: N/A
- Entrez ID: 5498
- UniProt: P50336
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
- UniProt Summary: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. {ECO:0000269|PubMed:21048046, ECO:0000269|PubMed:23467411, ECO:0000269|PubMed:7713909}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2963
- Expression level (log2 read counts): 3.78
PPOX Expression in NALM6 Cells: 3.78
