PPP1CC [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1CC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1CC
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 catalytic subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5501|5501]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36873|P36873]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1CC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1CC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PTW/PP1 phosphatase complex|
|protein phosphatase type 1 complex|
|positive regulation of glial cell proliferation|
|lamin binding|
|protein phosphatase 1 binding|
|entrainment of circadian clock by photoperiod|
|photoperiodism|
|entrainment of circadian clock|
|regulation of glial cell proliferation|
|phosphoprotein phosphatase activity|
|phosphatase activity|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|cleavage furrow|
|circadian regulation of gene expression|
|energy reserve metabolic process|
|protein serine/threonine phosphatase activity|
|positive regulation of gliogenesis|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|condensed chromosome kinetochore|
|presynapse|
|regulation of nucleocytoplasmic transport|
|protein N-terminus binding|
|nuclear chromosome, telomeric region|
|regulation of circadian rhythm|
|regulation of gliogenesis|
|circadian rhythm|
|dendritic spine|
|midbody|
|mitochondrial outer membrane|
|cellular carbohydrate metabolic process|
|protein C-terminus binding|
|protein dephosphorylation|
|energy derivation by oxidation of organic compounds|
|protein domain specific binding|
|protein-containing complex binding|
|rhythmic process|
|response to light stimulus|
|dephosphorylation|
|glutamatergic synapse|
|regulation of intracellular transport|
|nuclear speck|
|focal adhesion|
|generation of precursor metabolites and energy|
|response to radiation|
|protein kinase binding|
|positive regulation of neurogenesis|
|carbohydrate metabolic process|
|cell division|
|positive regulation of nervous system development|
|positive regulation of cell development|
|protein-containing complex|
|regulation of neurogenesis|
|nucleolus|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|neuron differentiation|
|response to abiotic stimulus|
|mitochondrion|
|cell cycle|
|positive regulation of developmental process|
|RNA binding|
|generation of neurons|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.08|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.85|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.83|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.84|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.13|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.18|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.51|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.84|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp1ca|PPP1CA]]|0.558|
|[[:human genes:a:atat1|ATAT1]]|0.442|
|[[:human genes:p:ppp1r2|PPP1R2]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1CC Expression in NALM6 Cells: 8.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>