PPP1CC

Gene Information

Official Symbol: PPP1CC
Official Name: protein phosphatase 1 catalytic subunit gamma
Aliases and Previous Symbols: N/A
Entrez ID: 5501
UniProt: P36873
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-2.08
Erlotinib 10μM R05 exp216	-1.85
Epothilone-B 0.0015μM R05 exp231	1.83
UM131593 0.2μM R03 exp106	1.84
Demecolcine 0.03μM R05 exp228	2.13
UMK57 1μM R01 exp59	2.18
Taxol 0.004μM R03 exp103	2.51
RO-3307 4.7μM R02 exp80	2.79
Mdivi-1 15μM R05 exp217	2.84
Colchicine 0.009μM R05 exp215	3.02

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13992
Expression level (log2 read counts): 8.05

Expression Distribution

Gene	Correlation
PPP1CA	0.558
ATAT1	0.442
PPP1R2	0.424

PTW/PP1 phosphatase complex
protein phosphatase type 1 complex
positive regulation of glial cell proliferation
lamin binding
protein phosphatase 1 binding
entrainment of circadian clock by photoperiod
photoperiodism
entrainment of circadian clock
regulation of glial cell proliferation
phosphoprotein phosphatase activity
phosphatase activity
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
cleavage furrow
circadian regulation of gene expression
energy reserve metabolic process
protein serine/threonine phosphatase activity
positive regulation of gliogenesis
cellular polysaccharide metabolic process
polysaccharide metabolic process
condensed chromosome kinetochore
presynapse
regulation of nucleocytoplasmic transport
protein N-terminus binding
nuclear chromosome, telomeric region
regulation of circadian rhythm
regulation of gliogenesis
circadian rhythm
dendritic spine
midbody
mitochondrial outer membrane
cellular carbohydrate metabolic process
protein C-terminus binding
protein dephosphorylation
energy derivation by oxidation of organic compounds
protein domain specific binding
protein-containing complex binding
rhythmic process
response to light stimulus