PPP1R11 [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R11
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory inhibitor subunit 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6992|6992]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60927|O60927]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram- positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PPI Ypi1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein phosphatase type 1 complex|
|protein serine/threonine phosphatase inhibitor activity|
|protein phosphatase 1 binding|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|negative regulation of cytokine secretion|
|defense response to Gram-positive bacterium|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of dephosphorylation|
|ubiquitin protein ligase activity|
|negative regulation of secretion|
|negative regulation of cytokine production|
|defense response to bacterium|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|regulation of secretion|
|cellular macromolecule catabolic process|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 307/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|8/28|
|bone|14/26|
|breast|16/33|
|central nervous system|20/56|
|cervix|0/4|
|colorectal|9/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|15/21|
|liver|9/20|
|lung|35/75|
|lymphocyte|4/16|
|ovary|10/26|
|pancreas|9/24|
|peripheral nervous system|2/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R11 Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>