PPP1R11

Gene Information

Official Symbol: PPP1R11
Official Name: protein phosphatase 1 regulatory inhibitor subunit 11
Aliases and Previous Symbols: N/A
Entrez ID: 6992
UniProt: O60927
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram- positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 307/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	12/28
blood	8/28
bone	14/26
breast	16/33
central nervous system	20/56
cervix	0/4
colorectal	9/17
esophagus	7/13
fibroblast	1/1
gastric	6/16
kidney	15/21
liver	9/20
lung	35/75
lymphocyte	4/16
ovary	10/26
pancreas	9/24
peripheral nervous system	2/16
plasma cell	5/15
prostate	1/1
skin	12/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	9/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1614
Expression level (log2 read counts): 4.64

Expression Distribution

protein phosphatase type 1 complex
protein serine/threonine phosphatase inhibitor activity
protein phosphatase 1 binding
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of cytokine secretion
defense response to Gram-positive bacterium
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of protein dephosphorylation
regulation of phosphatase activity
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
regulation of dephosphorylation
ubiquitin protein ligase activity
negative regulation of secretion
negative regulation of cytokine production
defense response to bacterium
negative regulation of hydrolase activity
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
proteolysis involved in cellular protein catabolic process
negative regulation of protein modification process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
response to bacterium
regulation of cytokine production
regulation of protein transport