PPP1R13L [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R13L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R13L
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 13 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10848|10848]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUF5|Q8WUF5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R13L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R13L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|Ank 2|
|Ank|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac right ventricle morphogenesis|
|embryonic camera-type eye development|
|ventricular cardiac muscle tissue development|
|intercellular bridge|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|multicellular organism growth|
|heart contraction|
|post-embryonic development|
|hair cycle|
|molting cycle|
|heart process|
|striated muscle contraction|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of signal transduction by p53 class mediator|
|transcription corepressor activity|
|heart morphogenesis|
|muscle contraction|
|striated muscle tissue development|
|muscle tissue development|
|muscle system process|
|cadherin binding|
|camera-type eye development|
|multicellular organismal homeostasis|
|transcription factor binding|
|eye development|
|visual system development|
|sensory system development|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|embryonic organ development|
|heart development|
|sensory organ development|
|cell junction|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|apoptotic process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|programmed cell death|
|identical protein binding|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.31|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.96|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.415|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.415|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.415|
|[[:human genes:c:copa|COPA]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2255
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R13L Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>