PPP1R13L

Entrez Summary: N/A
UniProt Summary: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cardiac right ventricle morphogenesis
embryonic camera-type eye development
ventricular cardiac muscle tissue development
intercellular bridge
cardiac ventricle morphogenesis
cardiac muscle contraction
multicellular organism growth
heart contraction
post-embryonic development
hair cycle
molting cycle
heart process
striated muscle contraction
cardiac chamber morphogenesis
cardiac ventricle development
cardiac muscle tissue development
cardiac chamber development
regulation of signal transduction by p53 class mediator
transcription corepressor activity
heart morphogenesis
muscle contraction
striated muscle tissue development
muscle tissue development
muscle system process
cadherin binding
camera-type eye development
multicellular organismal homeostasis
transcription factor binding
eye development
visual system development
sensory system development
developmental growth
blood circulation
growth
circulatory system process
embryonic organ development
heart development
sensory organ development
cell junction
transcription, DNA-templated