PPP1R3F

Entrez Summary: This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: Glycogen-targeting subunit for protein phosphatase 1 (PP1). {ECO:0000269|PubMed:21668450}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Golgicide-A 2μM R03 exp121	1.76
SB203580 25μM R03 exp149	1.78

glycogen binding
regulation of glycogen (starch) synthase activity
regulation of glycogen biosynthetic process
regulation of glucan biosynthetic process
regulation of glycogen metabolic process
regulation of polysaccharide biosynthetic process
regulation of polysaccharide metabolic process
protein phosphatase binding
regulation of carbohydrate biosynthetic process
regulation of glucose metabolic process
regulation of cellular carbohydrate metabolic process
regulation of generation of precursor metabolites and energy
regulation of carbohydrate metabolic process
regulation of small molecule metabolic process
regulation of transferase activity
membrane