PPP2R5A

Gene Information

Official Symbol: PPP2R5A
Official Name: protein phosphatase 2 regulatory subunit B'alpha
Aliases and Previous Symbols: N/A
Entrez ID: 5525
UniProt: Q15172
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16995
Expression level (log2 read counts): 5.31

Expression Distribution

Screen	Score
GSK461364A 0.1μM R03 exp126	1.71
HMS-I2 10μM R06 exp288	1.73

negative regulation of lipid kinase activity
protein phosphatase activator activity
protein phosphatase type 2A complex
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell periphery
M band
negative regulation of protein localization to membrane
protein phosphatase regulator activity
phosphoprotein phosphatase activity
positive regulation of protein dephosphorylation
regulation of protein autophosphorylation
chromosome, centromeric region
positive regulation of dephosphorylation
regulation of lipid kinase activity
negative regulation of lipid metabolic process
kinase binding
regulation of protein localization to plasma membrane
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
regulation of phosphoprotein phosphatase activity
Z disc
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of protein localization to membrane
regulation of dephosphorylation
protein dephosphorylation
negative regulation of kinase activity
negative regulation of transferase activity
dephosphorylation
regulation of lipid metabolic process
negative regulation of phosphorylation
centrosome
regulation of cellular protein localization
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of catalytic activity
regulation of kinase activity
regulation of cellular localization
regulation of transferase activity
regulation of protein localization