PPP3R1 [The Human Chemical-Genetic Interaction Map Project]

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======= PPP3R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP3R1
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 3 regulatory subunit B, alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5534|5534]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63098|P63098]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP3R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP3R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601302|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent protein serine/threonine phosphatase activity|
|calcineurin complex|
|calcineurin-NFAT signaling cascade|
|calcineurin-mediated signaling|
|cyclosporin A binding|
|inositol phosphate-mediated signaling|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|Wnt signaling pathway, calcium modulating pathway|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|phosphatase binding|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|sarcolemma|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|non-canonical Wnt signaling pathway|
|calcium-mediated signaling|
|Fc-epsilon receptor signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|calmodulin binding|
|protein dephosphorylation|
|mitochondrial transport|
|Fc receptor signaling pathway|
|protein domain specific binding|
|dephosphorylation|
|positive regulation of cellular protein localization|
|second-messenger-mediated signaling|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of apoptotic signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of cellular protein localization|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|calcium ion binding|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of protein localization|
|cell-cell signaling|
|regulation of immune response|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|mitochondrion|
|regulation of organelle organization|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.13|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.36|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.89|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.89|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.88|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.87|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.85|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.82|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.79|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.73|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.74|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.77|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.84|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.92|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.93|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.93|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.94|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.97|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.99|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.02|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.02|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.03|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.06|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.07|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.15|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.29|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.64|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.68|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.68|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.7|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.76|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.85|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.05|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.16|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.41|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|3.41|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|3.47|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|3.5|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.58|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|3.59|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|4.2|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|4.31|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|4.37|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|4.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|5.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp3ca|PPP3CA]]|0.704|
|[[:human genes:n:nfatc3|NFATC3]]|0.655|
|[[:human genes:i:itpr1|ITPR1]]|0.58|
|[[:human genes:g:gna15|GNA15]]|0.474|
|[[:human genes:l:lpar5|LPAR5]]|0.459|
|[[:human genes:r:rrm1|RRM1]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3948
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP3R1 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>