PPP3R1
Gene Information
- Official Symbol: PPP3R1
- Official Name: protein phosphatase 3 regulatory subunit B, alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5534
- UniProt: P63098
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Pfam Domains GO Terms
Pfam Domains
| efhand |
GO Terms
| calcium-dependent protein serine/threonine phosphatase activity |
| calcineurin complex |
| calcineurin-NFAT signaling cascade |
| calcineurin-mediated signaling |
| cyclosporin A binding |
| inositol phosphate-mediated signaling |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| Wnt signaling pathway, calcium modulating pathway |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| phosphatase binding |
| positive regulation of establishment of protein localization to mitochondrion |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| regulation of membrane permeability |
| sarcolemma |
| positive regulation of mitochondrion organization |
| positive regulation of protein localization to membrane |
| mitochondrial membrane organization |
| non-canonical Wnt signaling pathway |
| calcium-mediated signaling |
| Fc-epsilon receptor signaling pathway |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| regulation of protein localization to membrane |
| calmodulin binding |
| protein dephosphorylation |
| mitochondrial transport |
| Fc receptor signaling pathway |
| protein domain specific binding |
| dephosphorylation |
| positive regulation of cellular protein localization |
| second-messenger-mediated signaling |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of apoptotic signaling pathway |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| mitochondrion organization |
| positive regulation of establishment of protein localization |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of cellular protein localization |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| calcium ion binding |
| regulation of establishment of protein localization |
| membrane organization |
| regulation of cellular localization |
| positive regulation of transport |
| regulation of protein localization |
| cell-cell signaling |
| regulation of immune response |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| mitochondrion |
| regulation of organelle organization |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of RNA metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3948
- Expression level (log2 read counts): 6.12
Expression Distribution
PPP3R1 Expression in NALM6 Cells: 6.12
