PPY

Entrez Summary: N/A
UniProt Summary: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 14/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.76
UM131593 0.1μM R01 exp58	-1.76

neuropeptide hormone activity
G protein-coupled receptor binding
hormone activity
neuropeptide signaling pathway
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
secretion by cell
export from cell
secretion
G protein-coupled receptor signaling pathway
protein transport
peptide transport
amide transport
extracellular space
establishment of protein localization
nitrogen compound transport
extracellular region