PRB3
Gene Information
- Official Symbol: PRB3
- Official Name: proline rich protein BstNI subfamily 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5544
- UniProt: Q04118
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Long' allele. The protein isoforms encoded by this gene are recognized as the 'first line of oral defense' against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015].
- UniProt Summary: Acts as a receptor for the Gram-negative bacterium F.nucleatum. {ECO:0000269|PubMed:1894623}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14043
- Expression level (log2 read counts): -3.59
PRB3 Expression in NALM6 Cells: -3.59
