PRDM14

Entrez Summary: N/A
UniProt Summary: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. {ECO:0000250|UniProtKB:E9Q3T6, ECO:0000269|PubMed:17942894, ECO:0000269|PubMed:20953172}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inactivation of paternal X chromosome
histone H3-R26 methylation
inner cell mass cell fate commitment
germ-line stem cell population maintenance
inner cell mass cell differentiation
positive regulation of stem cell population maintenance
positive regulation of cilium-dependent cell motility
positive regulation of flagellated sperm motility
histone arginine methylation
peptidyl-arginine methylation
negative regulation of fibroblast growth factor receptor signaling pathway
regulation of flagellated sperm motility
dosage compensation by inactivation of X chromosome
dosage compensation
regulation of cilium-dependent cell motility
regulation of DNA methylation
peptidyl-arginine modification
regulation of stem cell population maintenance
regulation of fibroblast growth factor receptor signaling pathway
homeostasis of number of cells within a tissue
embryo implantation
blastocyst formation
methyltransferase activity
somatic stem cell population maintenance
chromatin DNA binding
positive regulation of reproductive process
cell fate specification
histone methylation
blastocyst development
protein methylation
protein alkylation
stem cell population maintenance
maintenance of cell number
negative regulation of cellular response to growth factor stimulus
regulation of reproductive process
fertilization
female pregnancy
tissue homeostasis
homeostasis of number of cells
multi-multicellular organism process