PRDM5

Entrez Summary: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
UniProt Summary: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. {ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019, ECO:0000269|PubMed:21664999}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H3-K9 methylation
histone H3-K9 modification
repressing transcription factor binding
histone deacetylation
protein deacetylation
methyltransferase activity
protein deacylation
macromolecule deacylation
chromatin DNA binding
histone lysine methylation
peptidyl-lysine methylation
histone methylation
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
protein methylation
protein alkylation
transcription regulatory region DNA binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
macromolecule methylation
nuclear body
methylation
peptidyl-lysine modification
RNA polymerase II regulatory region sequence-specific DNA binding
histone modification
covalent chromatin modification
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity
mitotic cell cycle
chromatin organization
nucleolus
negative regulation of transcription by RNA polymerase II
peptidyl-amino acid modification
cellular response to cytokine stimulus
chromosome organization
response to cytokine
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process