PRDX1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRDX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDX1
  * **<color #00a2e8>Official Name</color>**: peroxiredoxin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5052|5052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06830|Q06830]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Redoxin|
|1-cysPrx C|
|AhpC-TSA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thioredoxin peroxidase activity|
|removal of superoxide radicals|
|cellular response to oxygen radical|
|cellular response to superoxide|
|response to superoxide|
|response to oxygen radical|
|natural killer cell mediated cytotoxicity|
|hydrogen peroxide catabolic process|
|natural killer cell mediated immunity|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|leukocyte mediated cytotoxicity|
|antibiotic catabolic process|
|natural killer cell activation|
|cofactor catabolic process|
|retina homeostasis|
|cell redox homeostasis|
|cell killing|
|erythrocyte homeostasis|
|cellular oxidant detoxification|
|cellular detoxification|
|melanosome|
|antibiotic metabolic process|
|myeloid cell homeostasis|
|regulation of NIK/NF-kappaB signaling|
|reactive oxygen species metabolic process|
|detoxification|
|cellular response to reactive oxygen species|
|drug catabolic process|
|tissue homeostasis|
|response to reactive oxygen species|
|homeostasis of number of cells|
|cellular response to toxic substance|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|lymphocyte mediated immunity|
|cadherin binding|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|lymphocyte activation|
|response to oxidative stress|
|cofactor metabolic process|
|skeletal system development|
|drug metabolic process|
|response to toxic substance|
|response to inorganic substance|
|cell population proliferation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|innate immune response|
|leukocyte mediated immunity|
|cellular homeostasis|
|leukocyte activation|
|defense response to other organism|
|oxidation-reduction process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell activation|
|immune effector process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of protein phosphorylation|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|homeostatic process|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-4.74|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-4.38|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-4.21|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-3.77|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.74|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-3.53|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-3.34|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.77|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.15|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.89|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.83|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.81|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.76|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.75|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.72|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.72|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.15|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4518
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDX1 Expression in NALM6 Cells: 9.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>